PDZ domain

PDZ domain
Domains found in various intracellular signalling proteins associated with the plasma membrane; named for the postsynaptic density, disc-large, ZO-1 proteins in which they were first described. May mediate formation of membrane-bound macromolecular complexes, for example of receptors and channels, by homotypic interaction, also of cell-cell junctions. Usually bind to short linear C-terminal sequences in the protein with which they interact.
(= PSD-95/Discs large/zO-1 domain)
Domain involved in protein-protein interactions; binds to GLGF motif in binding partner.

Dictionary of molecular biology. 2004.

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